3/24/2023 0 Comments Typeeto trial![]() One of curcumin’s potential limitations is that it is poorly absorbed following ingestion hence there has been a tremendous interest in developing strategies to enhance its absorption and systemic bioavailability. Interestingly, growing body of data also indicate that in addition to curcumin, other constituents of turmeric, primarily essential turmeric oils (ETO) comprising of aromatic-tumerones (ar-tumerones), α-turmerones, β-turmerones, α-santalene and aromatic curcumene, also possess significant anti-inflammatory and anti-oxidant properties 7, 8, 9. In addition to its well-established anti-inflammatory properties, clinical studies in the recent years have highlighted its therapeutic efficacy in a variety of diseases including arthritis and depression 1, 2, as well as its potent anti-tumorigenic potential 3, 4, 5, 6. In particular, curcumin, the active principle extracted from the dried rhizomes of Curcuma longa (or turmeric) is perhaps one of most studied natural compounds within the context of complementary medicine. Turmeric has been used traditionally as a medicinal herb in India and South East Asia for thousands of years for various illnesses including biliary disorders, anorexia, coryza, cough, hepatic and rheumatic ailments and a variety of other chronic inflammatory diseases. Collectively, these findings suggest that the combined treatment of curcumin and essential turmeric oils provides superior protection from DSS-induced colitis than curcumin alone, highlighting the anti-inflammatory potential of turmeric. Gene expression analysis revealed that anti-inflammatory cytokines including IL-10 and IL-11 as well as FOXP3 were upregulated in the colon by ETO-curcumin. However, ETO-curcumin improved disease activity index (DAI) dose-dependently, while the anti-inflammatory efficacy of standard curcumin remained constant, suggesting that ETO-curcumin may provide superior anti-inflammatory efficacy compared to standard curcumin. ![]() The present study showed that both ETO and standard curcumin treatments provided protection against DSS-induced inflammation. Herein, we investigated anti-inflammatory efficacy and associated gene expression alterations of a specific, curcumin preparation containing essential turmeric oils (ETO-curcumin) in comparison to standard curcumin at three specific doses (0, 5, 25 or 50 mg/kg), in an animal model of dextran sodium sulfate (DSS)-induced colitis. Although curcumin is the most studied active constituents of turmeric, accumulating evidence suggests that other components of turmeric have additional anti-inflammatory and anti-tumorigenic properties. Turmeric has been used as a medicinal herb for thousands of years for treatment of various disorders. ![]()
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